Cash was stolen during a break-in at Joymount Presbyterian Church in Carrick after the service on Sunday.
Police have described the burglary as “despicable”.
A spokesperson for PSNI Carrickfergus said: “A large glass bottle containing loose change from collections sitting in the main front hall has been emptied.”
This contained £150 which had been earmarked for good causes.
The spokesperson continued: “An office room upstairs was entered and a cash box containing £50 was also taken from the youth club outing fund.”
Police believe that the break-in occurred sometime between 1.00 pm and 8.00 pm on Sunday.
The PSNI spokesperson added: “Burglary in itself is a pretty despicable act as it is a major violation of someone’s home. But to burgle a church is quite simply low. As I said it means a lot to some people and to have money taken that was set aside to help others is despicable.
“If anyone has information in relation to this despicable crime, can they contact police on 101 with reference number 725 of 26/11/18 or contact Crimestoppers anonymously on 0800 555 111.”